Atletico Madrid and Real Madrid will face off again on Wednesday night for the second leg of their Champions League last-16 tie at the Metropolitano, with Los Blancos holding a 2-1 advantage after a thrilling first leg last week. Brahim Diaz scored a dramatic late winner for Carlo Ancelotti’s side at the Bernabeu last Tuesday, following stunning goals from Rodrygo and Julian Alvarez in both halves. Historically, this fixture in the Champions League has favored Real Madrid, whether in the 2014 and 2016 finals or the 2017 semi-finals. However, Atletico can take some comfort from their strong record at home against their bitter rivals, having lost just once in their last seven encounters at the Metropolitano. In cup competitions, Atletico are unbeaten in their last five meetings with Real Madrid, winning four. To stay in contention for progression, they must claim victory here after last week's defeat. Atletico have faced the challenge of losing the first leg in a Champions League knockout tie six times before but have still managed to advance three times, all through remarkable comebacks at home in the second leg. Manager Diego Simeone will be hoping for another turnaround like last season when Atletico overturned a one-goal deficit against Inter Milan in the last 16. Given Atletico's formidable home form in Europe, Real Madrid will know this is no ordinary challenge. The hosts haven’t lost at home in the knockout stages of the Champions League in 28 years, maintaining an unbeaten record across 18 matches since Ajax won at the Vicente Calderon in March 1997. After winning eight consecutive away games at the Calderon between 2008 and 2014, Real Madrid have since struggled in the fixture, claiming just three victories in their last 17 visits to Atletico’s new home. Atletico Madrid vs Real Madrid Odds Atletico - 6/4 (CopyBet) Draw - 5/2 (CopyBet) Real Madrid - 13/8 (CopyBet) 18+ | Gamble responsibly | gambleaware.org| Odds subject to change Atletico Madrid vs Real Madrid Betting Tips Real Madrid to win in extra time - 13/1 (CopyBet) Atletico to win on penalties - 13/1 (CopyBet) Real Madrid to score - 1/4 (CopyBet) 18+ | Gamble responsibly |gambleaware.org | Odds subject to change Atletico Madrid vs Real Madrid Betting Offer Bookies CopyBet are offering new customers £60 free bets when they place a £20 qualifying bet. Simply register and bet £20 on a single bet on the match on minimum 1.9 odds and CopyBet will give you three free bets worth £20 each to place on football, horse racing and other popular sports too. Full T&Cs apply. New UK customers only. The qualifying bet should be either a Single or Acca (2+ selections) bet, start at £20, have 1.9 or greater odds and must be settled within 7 days of opt-in. 3 Free bets include: 1 x £20 Free bet Racing (Horse Racing or Greyhound Racing); 1 x £20 Free Bet Live Football; 1 x £20 Free Bet Live. Max payout – £500. 7-day expiry. To unlock the offer, complete the first deposit via the banking app (Open banking). 18+. Full terms and conditions apply |gambleaware.org | Gamble responsibly | 18+ | UK only READ MORE: Free Bets & Bookmaker Sign Up Offers Gamble responsibly Reach plc is committed to promoting safer gambling. All of our content and recommended bets are advised to those aged 18 or over. Odds are subject to change too. We strongly encourage our readers to only ever bet what they can afford to lose. For more information, please call the National Gambling Helpline on 0808 8020 133 or visit gambleaware.org.