Athletic Bilbao remained on course towards a Europa League final at their home stadium with a 3-1 victory over 10-man Roma to reach the quarter-finals.
They will be joined by 2022 champions Eintracht Frankfurt, Lazio and Bodø/Glimt, after the early matches were completed on Thursday.
Bilbao overturned a 2-1 deficit from the first leg in Rome from Nico Williams' brace and Yuri Berchiche.
Spanish Euro 2024 champion Williams opened the scoring in first half-stoppage time, off his brother Inaki Williams. Berchiche's glancing header into the far right corner in the 68th made it 2-0 and Williams wrapped up matters in the 82nd after a one-two with Berchiche.
Roma had former Germany defender Mats Hummels sent off in the 11th minute for a last-man foul on Maroan Sannadi, and Leandro Paredes' stoppage time penalty came too late for them.
Frankfurt followed up on their 2-1 success at Ajax last week with a 4-1 home victory over the Amsterdam side which included a brace from German 2014 World Cup hero Mario Götze.
Jean-Matteo Bahoya opened the scoring seven minutes into the game after a one-two with Hugo Ekitike, and Götze scored a classy second in the 25th when he chested a long over-the-top pass from Robin Koch and fired home.
Ekitike drilled the third into the right corner in the 67th, Kenneth Taylor got a consolation goal for Ajax but Götze then struck the fourth from a distance in the 82nd after Ajax goalkeeper Matheus had tried to clear far out of his penalty area.
Bodø/Glimt reached a European quarter-final for a second time, 4-2 on aggregate over reigning Conference League champions Olympiacos.
Coming off a 3-0 home triumph, the Norwegians could afford a 2-1 defeat from Roman Yaremchuk's brace in Piraeus where the hosts had goalkeeper Konstantinos Tzolakis sent off and Rodinei failing to convert a penalty.
Lazio won their last 16 tie 3-2 over Viktoria Plzen from a 1-1 home draw.
In the quarter-finals, Bilbao play either Rangers or Jose Mourinho's Fenerbahce, Frankfurt face Tottenham Hotspur or another Dutch opponent in AZ Alkmaar, while Bodø/Glimt are up against Lazio.
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