In the latest case, a total of 40 defendants were accused of "conspiracy against state security" and "belonging to a terrorist group". Most had left the country and were tried in absentia.
Those in detention include National Salvation Front leaders Issam Chebbi and Jawhar Ben Mbarek.
They were given 18-year sentences, a defence lawyer told AFP news agency following the ruling late on Friday.
Kamel Eltaief, an activist and businessman, was jailed for 66 years, the lawyer added.
Kamel Jendoubi, a former minister who was tried in absentia, told AFP news agency: "This is not a judiciary ruling, but a political decree executed by judges under orders."
Defence lawyer Ahmed Souab is quoted by Reuters news agency as saying: "I have never witnessed a trial like this. It's a farce."
Tunisia is the country where a wave of pro-democracy protests in the Arab world began in late 2010. The country's long-time strongman, Zine El Abidine Ben Ali, was ousted within weeks.
Last year's election was Tunisia's third presidential vote since then.
Rights group Amnesty International has denounced "a worrying decline in fundamental rights" under Saied's government as discontent rises over his authoritarian style of governance.
Saied has rejected the criticism, saying he is fighting a "corrupt elite" and "traitors".
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