Dan Biggar has described this fixture as Wales' most important game of the last 15 to 20 years. Talk about piling on the pressure! Italy are after back to back wins against the Welsh for the first time ever - and a first win in Rome in the fixture since 2007. After the disappointment of losing to Scotland last week, they are favourites to make it happen as Warren Gatland's side are in a dark place. Their 43-0 defeat to France on this tournament's opening night extended their record-breaking losing streak to 13 games. The run has to stop sometime but the Stadio Olimpico may not be the place. With Ireland up next, Gatland is praying that his side can get something going in Rome. “We have spoken as a group just about how important this game is for us,” Gatland said. “The players have responded well, in terms of taking some leadership and ownership this week. They are aware of how important this game is. “You try and be positive as much as you possibly can. You try not to look at the white noise from the outside. We are focusing on ourselves. “The thing with the Italian team is when they are in the fight and in the game, that is when they are hard to put away, so we have got to make sure we start well, look at taking points and put scoreboard pressure on them.” What time is kick-off? The match kicks off at on Saturday at 2.15pm What TV channel is it on? You can watch the game on Virgin Media One from 1.30pm and on ITV 1. Italy to win 2/5; Scotland to win 11/5; Draw 22/1 Wales fought hard against France but lacked an attacking game plan to hurt Les Bleus. Gatland has made two changes from that line-up. Scarlets centre Eddie James in for his first Test start for the injured Owen Watkin while there is a recall for the 104-times capped Taulupe Faletau, the No.8 making his return to the international fray for the first time in almost 18 months since he suffered a broken arm and then a fractured shoulder. Italy, meanwhile, have made two changes to their matchday 23. Into the line-up comes Benetton's Niccoló Cannone as a second row replacement for Dino Lamb, while Jacopo Trulla is added to the bench for the injured Simone Gesi. Wales: Liam Williams, Tom Rogers, Nick Tompkins, Eddie James, Josh Adams, Ben Thomas, Tomos Williams; Gareth Thomas, Evan Lloyd, Henry Thomas, Will Rowlands, Dafydd Jenkins, James Botham, Jac Morgan (captain), Taulupe Faletau. Replacements: Elliot Dee, Nicky Smith, Keiron Assiratti, Freddie Thomas, Aaron Wainwright, Rhodri Williams, Dan Edwards, Blair Murray Italy: Tommaso Allan, Ange Capuozzo, Juan Ignacio Brex, Tommaso Menoncello, Monty Ioane, Paolo Garbisi, Page-Relo; Danilo Fischetti, Giacomo Nicotera, Simone Ferrari, Niccolo Cannone, Federico Ruzza, Sebastian Negri, Michele Lamaro, Lorenzo Cannonne. Replacements: Gianmarco Lucchesi, Lica Rizzioli, Marco Riccioni, Dino Lamb, Manuel Zuliani, Ross Vintcent, Alessandro Garbisi, Jacopo Trulla. The Irish Mirror has a rugby WhatsApp group where you can get breaking news and top stories on Ireland's Six Nations campaign straight to your phone. Click here to join. You can leave our group at any time if you don't like it.