The Killers won the special international prize, with Bruce Springsteen handing over the trophy to frontman Brandon Flowers.
The singer joked that "the only downside" of the award was that "it feels one giant step away from fulfilling my original dream of becoming the most sought-after valet on the Las Vegas strip".
Backstage, Flowers was somewhat overwhelmed by Springsteen's presence.
"That was really cool," he told BBC News. "He went out of his way to come here. I love him.
Lola Young won the rising star award, recognising the success of her breakthrough single, Messy.
"This is such a big moment for the kid in my bedroom that was 10 years old, writing songs on her guitar," the 24-year-old musician told the BBC.
"To be here now is such an honor, and such a gives me such a warm feeling."
Young also revealed she'd recently finished her next album, and "shot 12 music videos in one day" to accompany her new songs.
Myles Smith's Stargazing was named the most-played song on UK radio last year.
"The first time I heard it on the radio was actually in New York," he said. "I remember it so specifically. I was in an Uber and the song came on, and I told the driver, 'This is me' and he could not care less.
"It was the best way to be humbled, and it really kept me grounded from year one."
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