Duran scored his second and Al Nassr's fourth four minutes after the break, and Anderson Lopes grabbed a consolation for the five-time Japanese champion.
Al Nassr's Saudi Pro League rival Al Ahli defeated Buriram United of Thailand 3-0.
The damage was done early. After just four minutes, former Manchester City star Riyad Mahrez scored with a low shot from the right side of the area after Buriram failed to clear. Two minutes later, Brazilian winger Galeno made it 2-0 and Roberto Firmino finished off.
Al Ahli, a two-time finalist, will take on Al Hilal, the four-time champion, in an all-Saudi semifinal on Tuesday.
On Friday, Al Hilal thrashed Gwangju 7-0 with all seven coming from different scorers.
After Al Hilal's relatively poor run of form domestically, coach Jorge Jesus was delighted with the result and performance. "We've been under pressure in the Saudi Pro League, and the players have shown great focus despite that," Jesus said.
"Without commitment, we couldn't have achieved this. I believe we're on the right path, creating a good atmosphere for everyone involved -- players and staff."
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